Skip to content
ProBioGen_Logo_M_RGB

Gene Delivery

Advance your Cell Line Development with a powerful gene delivery system, which is based on a highly active transposase fusion variant that enables epigenetic targeting and a carefully designed transposon.

Your CDMO Partner
for

We develop and manufacture your biopharmaceutical drug candidate – reliably and rapidly. Our innovative technologies can elevate your product to the highest yield, potency, quality, and safety levels.

DirectedLuck® Transposase for advanced Cell Line Development

DirectedLuck® builds on a transposase's principle but with additional major improvements. It has been optimized to recognize specific chromatin marks, guiding the transgene to genomic regions with the highest transcriptional activity, which ensures exceptionally high protein expression and maximum stability. The clone pools generated within days to weeks are highly representative of later clones. The DirectedLuck® transposase is compatible with additional genetic elements in standard expression vector design and can be used with any host cell line from different species and tissue origin.
DirectedLuck® has been applied to develop cell lines for standard mAbs, complex glycoproteins and bispecifics and is also applicable beyond protein and virus production in cell and gene therapy.

DirectedLuck Transposase 1600px
231031_figures DirectedLuck fact sheet_epigenetic targeting at work

Features and Data

 

  Epigenetic targeting for highly efficient gene delivery

  Thoroughly designed transposase and transposon

  Moderate gene copy numbers and clean integration structures

  Hundreds of producer cell lines generated at ProBioGen or in licensee labs

 Short cut to viral vectors for CGT: stable packaging cells and CAR-Ts

 

 

Elevate your Gene Delivery

Untitled-1-05-1-1-1

Direct your transgenes right on point

  • Integration at genomic sites with highest activity
  • Maximum benefit from superior genomic harbors and transposon elements

Untitled-1-01-2

Get exceptional Product Quality

  • Bulk pools are predictable for clones
  • Surpreme heterodimer content for bispecifics

Untitled-1-08-1

Take the fast path to clinic

  • Highly stable bulk pools to manufacture material for TOX studies
  • Streamlines cell line development

ProBioGen - Your Integrated CDMO and Technology Expert for Biologics and Advanced Therapies

ProBioGen is a Berlin-based specialist for developing and manufacturing biopharmaceutical active ingredients, viral vectors and vaccines with applying proprietary technologies to improve product quality and features. Combining both state-of-the-art development services, together with intelligent product-specific technologies yields biologics with optimized properties. Rapid and integrated cell line and process development, comprehensive analytical development and GMP-compliant manufacturing is performed by a highly skilled and experienced team.

Portfolio Butterfly Open file RGB-02-1

 

Learn More about DirectedLuck® :

Possible Use Cases 

Features and Performance

Licensing conditions 

… how you can benefit from this outstanding gene delivery system!

 

 

 

Sign up for a 30 minutes Discovery Call

Get in touch to see what we have to offer in order to meet your individual needs.

 

Learn more about our DirectedLuck(R) Transposase System

ProBioGen AG

Headquarters:
Herbert-Bayer-Straße 8
13086 Berlin, Germany
Phone: +49 (0) 30 3229 35 100
 
Follow us
 
 
 
Copyright © 2023 ProBioGen AG
" frameborder="0" style="border:0;" allowfullscreen="" aria-hidden="false" tabindex="0">