Gene Delivery
Advance your Cell Line Development with a powerful gene delivery system, which is based on a highly active transposase fusion variant that enables epigenetic targeting and a carefully designed transposon.
Your CDMO Partner
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We develop and manufacture your biopharmaceutical drug candidate – reliably and rapidly. Our innovative technologies can elevate your product to the highest yield, potency, quality, and safety levels.
DirectedLuck® Transposase for advanced Cell Line Development
DirectedLuck® builds on a transposase's principle but with additional major improvements. It has been optimized to recognize specific chromatin marks, guiding the transgene to genomic regions with the highest transcriptional activity, which ensures exceptionally high protein expression and maximum stability. The clone pools generated within days to weeks are highly representative of later clones. The DirectedLuck® transposase is compatible with additional genetic elements in standard expression vector design and can be used with any host cell line from different species and tissue origin.
DirectedLuck® has been applied to develop cell lines for standard mAbs, complex glycoproteins and bispecifics and is also applicable beyond protein and virus production in cell and gene therapy.
Features and Data
Epigenetic targeting for highly efficient gene delivery
Thoroughly designed transposase and transposon
Moderate gene copy numbers and clean integration structures
Short cut to viral vectors for CGT: stable packaging cells and CAR-Ts
Hundreds of producer cell lines generated at ProBioGen or in licensee labs
Direct Your Transgenes Right on Point
- Integration at genomic sites with highest activity
- Maximum benefit from superior genomic harbors and transposon elements
Take the Fast Path to Clinic
- Highly stable bulk pools to manufacture material for TOX studies
- Streamlines cell line development
Get Exceptional Product Quality
- Bulk pools are predictable for clones
- Surpreme heterodimer content for bispecifics
ProBioGen - Your Integrated CDMO and Technology Expert for Biologics and Advanced Therapies
ProBioGen is a Berlin-based specialist for developing and manufacturing biopharmaceutical active ingredients, viral vectors and vaccines with applying proprietary technologies to improve product quality and features. Combining both state-of-the-art development services, together with intelligent product-specific technologies yields biologics with optimized properties. Rapid and integrated cell line and process development, comprehensive analytical development and GMP-compliant manufacturing is performed by a highly skilled and experienced team.
ProBioGen AG
Headquarter:
Herbert-Bayer-Straße 8
13086 Berlin, Germany
Phone: +49 (0) 30 3229 35 100
Email: info@probiogen.de
